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An interactive computer program for stereochemical analysis

and heuristic synthesis planning


The Chiron Program* is an interactive computer program for synthesis planning developed in the laboratories of Professor Stephen Hanessian at the Université de Montréal since 1985.

The Chiron Program offers the user some unique capabilities for the analysis and perception of stereochemical features in organic molecules and for the selection of precursors or starting materials.  Its strongest attribute is the speed with which it can carry out such operations, since these would normally require a much longer period of time if done visually, even with the aid of molecular models.

The Chiron Program will "see" a molecule in a multitude of 2D perspectives and it will present the user with possibilities for synthetic options that may have otherwise eluded the human eye. The Chiron Program will decode the stereochemical and functional complexities of a target structure and relate them to structures or sub-structures derived from more than 200,000 precursors or starting materials.

The program consists of four modules: CARS-2D (Computer Assisted Reaction Schemes), CASA (Computer Assited Stereochemical Analysis), CAPS (Computer Assited Precursor Selection) and CARS-3D (3D drawing and simulation). There is a fifth module that works on IRIS systems, allows manipulation in real time and 3D visualization.

* The name Chiron is derived from "chiral synthon". See "Total Synthesis of Natural Products - The 'Chiron' Approach", S. Hanessian, Pergamon Press, Oxford, U.K. 1983; Aldrichimica Acta, 1989, 22, No.1

The Chiron Program works on Silicon Graphics, Apple Macintosh and Windows based computers.


Copyright © 2009 Department of Chemistry, University of Montreal