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The Chiron Program*
is an interactive computer program
for synthesis planning developed in the laboratories of Professor Stephen Hanessian
at the Université de Montréal since 1985.
The Chiron Program offers the user some unique
capabilities for the analysis and perception of
stereochemical features in organic molecules
and for the selection of precursors or starting materials. Its
strongest attribute is the speed with which it can carry out
such operations, since these would normally require a much
longer period of time if done visually, even with the aid of
molecular models. |
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The Chiron Program will "see" a molecule in a multitude
of 2D perspectives and it will present the user with possibilities
for synthetic options that may have otherwise eluded the
human eye. The Chiron Program will decode the
stereochemical and functional complexities of a target structure
and relate them to structures or sub-structures derived from
more than 200,000
precursors or starting materials.
The program consists of four modules:
CARS-2D (Computer Assisted Reaction Schemes),
CASA (Computer Assited Stereochemical Analysis),
CAPS (Computer Assited Precursor Selection) and
CARS-3D (3D drawing and simulation). There is a fifth module
that works on IRIS systems, allows manipulation in real time
and 3D visualization.
* The name Chiron is derived from "chiral synthon".
See "Total Synthesis of Natural Products - The 'Chiron'
Approach", S. Hanessian, Pergamon Press, Oxford, U.K. 1983;
Aldrichimica Acta, 1989, 22, No.1
The Chiron Program works on Silicon Graphics, Apple
Macintosh and Windows based computers.
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